Wednesday, March 7, 2012

Autoimmune Diseases



Autoimmune diseases arise from the overactive immune response of the body against substances and tissues normally present in the body. In other words, the body's own cells attack instead. This can be restricted to specific organs (e.g. in tiroiditis) or involve specific tissue in different places (e.g. Goodpasture's disease that can affect both the basal membrane in the lungs and kidneys). Treatment of autoimmune diseases usually with immunosuppression — medication that lowers the body's immune response. There is an ongoing discussion about when autoimmune disease should be considered, which leads to different criteria as Witebsky's postulates. Causes may include molecular mimicry, or the presence of fetal cells in maternal blood flow, i.e. microchimerism, and infection with certain viruses and bacteria.
 
Autoimmune diseases occur when the immune or immune system within which should serve against the disease germ from outside the body actually attacks its own tissues. Some autoimmune diseases, including Lupus, Rheumatoid Arthritis and Multiple Sclerosis attacked women 2 to 10 times more than men. At first, the sex hormones is considered to play a role in autoimmune diseases.Found a nearly identical cell types in the blood of human autoimmune patients. In women with Rheumatoid Arthritis, the presence of these cells increases the growing age. When ABC ran out in mice, to auto immune disease rates down. This gives recommendations for potential treatment of autoimmune diseases.


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